Sir Alex Ferguson delivered the news in a press conference at Manchester United's Carrington training ground facility, where he also indicated that Jonny Evans could be fit to take his place in the back four.
Rooney, who has scored nine goals in his first five league matches this season, hasn't played since Manchester United's 3-1 win over Chelsea, while Javier Hernandez came off with dead leg early in last weekend's away game against Stoke City at the Britannia. Fergie said:
Wayne and Hernandez are fit for tomorrow. They trained very well yesterday, which is pleasing. We'll hopefully have Jonny Evans back too. At the moment we're making too many changes in the back four, so hopefully his return will help us with the defensive part.
Vidic, Cleverley and Smalling should be ready after the internationals and available for Liverpool.
After Tuesday's lacklustre draw with Basel in the Champions League, Sir Alex is keen to avoid a repeat performance, saying:
People will say our performance was careless (against Basel) and that we underestimated our opponents. I think there's an element of truth in that and we have to do better defensively.