Here are some of the teams that ESPN's experts didn't favor in their picks:
Buffalo Bills (vs. New England Patriots)
The Bills are a nice story at 2-0, but beating Tom Brady is another deal altogether.
The Patriots quarterback is 17-1 all-time against Buffalo. I'm sure someone wanted to pick the upset, but it's hard to bet against Brady right now.
Denver Broncos (vs. Tennessee Titans)
This is probably more a vote of confidence for the Titans than a knock on the Broncos, as Tennessee really bounced-back well against the Ravens in Week 2.
They could be a dark horse in the AFC South.
Minnesota Vikings (vs. Detroit Lions)
Less than two years ago, picking the Lions as a clear winner on the road at the Metrodome would have seemed crazy.
Today, the Lions look like the NFL's next best thing and the Vikings look lost. An 0-3 start appears headed Minnesota's way.
Houston Texans (vs. New Orleans Saints)
I thought at least someone would pick the Texans on the road, but it seems they still have something to prove.
New York Giants (vs. Philadelphia Eagles)
No love for the Giants?
Apparently not. The Eagles look like they will have Michael Vick, and that's enough for ESPN to unanimously pick Philly over New York.
I'm sure the Giants' front four will have something to say about that, however.
Jacksonville Jaguars (vs. Carolina Panthers)
This is an interesting early-season battle between rookie quarterbacks, but it's hard not to pick Cam Newton.
The No. 1 overall pick's back-to-back 400-yard games gives the pickers some confidence in him over Blaine Gabbert.
Kansas City Chiefs (vs. San Diego Chargers)
What a mess the Chiefs have become. Just a year after winning 10 games and the AFC West, they are the laughing stock of football.
Will they show some pride on the road in San Diego? The boys at ESPN don't seem to think so.
Seattle Seahawks (vs. Arizona Cardinals)
Where is the wisdom in signing Tarvaris Jackson, a career backup, and inserting him as your starting quarterback?
That plan has backfired miserably.
With T-Jax under center, I wouldn't be surprised to see the Seahawks as underdogs every week this season.
Indianapolis Colts (vs. Pittsburgh Steelers)
No Peyton Manning equals big trouble for the Colts against one of the NFL's best defenses.
Kerry Collins better be quick in his reads on Sunday or he might not make it 60 minutes.
Speaking of defense—or a lack thereof—the Colts run defense is just awful. Easy choice for ESPNers.