Both teams are coming off disappointing 0-1 starts in games where each team had a legitimate shot at winning their respective games.
A team is supposed to move on from a previous week's lost, but injures make it difficult to do so—especially when some of your more important players are injured.
Here are the four health issues to watch in NYC this Monday.
Steven Jackson was tearing up the Philadelphia Eagles on Sunday.
Jackson had 56 yards and a touchdown on only two touches for St. Louis Rams, but he hurt his right quadriceps on his lone touchdown run.
It's impossible for the Rams to replace Jackson's production outright, but Cadillac Williams did have 91 yards on 19 carries for a solid 4.8 yards-per-carry average.
He'll be hard-pressed to repeat the performance against a New York Giants team that can actually stop the run (the Washington Redskins only mustered 74 yards rushing), but Jackson hasn't ruled himself out yet.
It'll be a huge boost to the Rams if Jackson steps onto the field on Monday, both mentally and physically.
Hakeem Nicks has been listed as questionable for the greater part of this week, but it looks like Nicks is playing on against the St. Louis Rams on Monday.
Hakeem Nicks suffered a knee injury in the loss to the Washington Redskins, where he had seven catches for 122 yards.
Mario Manningham and Nicks are the future of the Giants at wide receiver.
Both players need to be healthy if the G-Men want to beat the Rams this coming Monday and make a serious playoff push this season.
Sam Bradford's right index finger injury left him unable to grip the ball in the fourth quarter against the Philadelphia Eagles.
The five sacks allowed on Bradford might've had something to do with it.
But now Bradford is healthy, and St. Louis Rams fans should breathe a sigh of relief that Bradford is suiting up for some Monday Night Football.
Bradford is the future of this Rams team, and he'll have a chance to sign given the New York Giants depleted secondary.
With Terrell Thomas out for the the season, as well as Prince Amukamara still sidelined, Bradford could put up an impressive performance.
But there still is one player he needs to worry about...
Justin Tuck was sidelined against the Washington Redksins last Sunday with an neck injury, but he's ready to go now.
Tuck the best player on the New York Giants.
He's the best defensive end in the league, and he's played four straight complete seasons.
While he's not maintaining that streak this season, Tuck is going to show NYG fans what they were missing on the pass rush when he was absent against the Redskins.