In most fantasy formats, you will only play one quarterback in your starting lineup. That makes the decision on who you are going to play very important. You really can't get a low, or negative, score at the position and expect to win.
In light of that, you have to play matchups sometimes. That might mean benching a more talented quarterback because he is facing a tough defense. The following three quarterbacks are guys you will want to avoid in week 2.
Cam Newton - Carolina Panthers
Given how well he played in his regular season debut last Sunday, it would be tempting to ride Cam Newton. There might be a time that you will be able to do that, but that time is not now.
There is a big difference in the Cardinals' defense and the Packers' defense. Newton will face growing pains at some point and they will likely start here in Week 2.
If you have Newton on your roster, it likely means that you have another quarterback. Almost regardless of who that other quarterback is, you'll want to go with him instead of Newton.
Matt Ryan- Atlanta Falcons
Some might argue that Ryan is too good a quarterback to bench at any time, but that's not the way I see it. Ryan struggled a little bit in the Falcons' Week 1 game against the Bears and those struggles will continue in Week 2 against a very talented Eagles defense.
This matchup play has almost as much to do with Ryan's receivers as it does with Ryan. Julio Jones, his second receiving option, has never dealt with a defense as physical as the one he is going to face on Sunday. Roddy White will have to deal with Nnamdi Asomugha, the top cornerback in the league.
There are very few weeks where you would consider benching Ryan for someone else, but this is one of them. If you have another option, consider making the switch.
Eli Manning- New York Giants
Eli Manning is a big name in the NFL, but he's not really all that big a name in fantasy circles. He has come to personify that second tier of quarterbacks behind the top eight or 10 in the league.
He didn't play all that well against the Redskins in Week 1 and there's no reason to believe that the level of his play will increase all that much in Week 2 against a talented Rams defense.
Not helping matters is the fact that Hakeem Nicks, his top receiver, is questionable for the game. It's unlikely you drafted Manning without having another decent quarterback on the roster. Go with the other guy this week.