Mike Tolbert limped off the field during the during the fourth quarter of the Chargers-Vikings game. 

Up until that point, Tolbert had been having a huge day, tallying 93 total yards and three touchdowns.  He and Ryan Mathews both received 12 carries on the day, but it was Tolbert's usage in the passing game—particularly in the red zone—that had his value ahead of Mathews.  On the day, Tolbert had nine receptions (on nine targets), serving as Philip Rivers' safety blanket all day.  

What it means for Tolbert owners if he's out multiple weeks:

Look for Ryan Mathews to pick up the red-zone series that Tolbert was getting.  Philip Rivers was looking often to the sturdy back, with the second of his two pass touchdowns coming off a broken play. 

Mathews would automatically become an RB1 in San Diego's offense.  He also looked strong on the day, racking up 73 yards on just three catches and another 45 yards on the ground.  If Tolbert is out for multiple weeks and Mathews starts getting red zone touches, it could amount to a huge fantasy and bounce back year for the second year player out of Fresno state. 

Additionally, marginal up ticks will go to big targets Malcolm Floyd and Vincent Jackson who could get more involved in the red zone offense.  But they'll still be behind Antonio Gates in the pecking order. 

I would say Gates' value goes up, but it really can't get any higher. 

Tolbert Injury Update:

As for Tolbert, he was seen lying on his back on the sidelines, while medical personnel examined him.  No further updates regarding his injury as of yet.