It will be interesting to see how Peyton Manning performs early on in the 2011 season, due his second offseason neck surgery in three years. Manning will still have a "Peyton Manning" type season, but I don't seem him as a main threat for the MVP this season.
Jones-Drew is about as talented as they come, but does he have the supporting cast around him? The Jaguars could go head into this year with rookie Blaine Gabbert as their starting quarterback, which will increase the pressure on Jones-Drew to preform.
Chris Johnson has yet to report to Titans camp, which could hinder his ability to start on opening day. Johnson would be a sure contender if it weren't for the contract dispute, and it wouldn't surprise me if he missed some game time.
Michael Vick is the epitome of a high-risk, high-reward player. Vick had a stellar season a year ago, but every defensive coordinator that knew they were going to face him spent a little more time in the film room than by the pool this offseason, and it wouldn't surprise me if they had his number.