It finally happened.
The Serb retired trailing 6-4, 3-0, to the Scot, who totally dominated play on court.
Djokovic will head into the 2011 US Open with a 57-2 record.
Djokovic's shoulder injury impeded his ability to compete with Murray during the final. The Scot started the match, breaking Djokovic's serve. It was not hard to see that the world No. 1 was not at his best serving or moving on the hard courts in Cincinnati.
Yet, the Serb managed to break back in the sixth game, leading to some speculation that Djokovic might be able to make his way back into the match, just as he has done so many times this summer.
Murray, however, quickly put an end to that belief, immediately breaking the Djokovic serve in the next game.
Murray took charge at that point, shutting the door on Djokovic's ability and his belief that he could find a way to win.
The Scot lost only one more game.
Djokovic called for the trainer after the third game in set two, having lost the opener. The Serb could not continue and retired from the match.
Murray needed the win to boost his confidence going into the US Open. It was the Scot's second win of the year. Murray had won the title in Cincinnati in 2008, again defeating Djokovic in the final. This win gave the Scot his seventh ATP Masters Shield.
This may prove to be real boost for Murray as he heads on to Flushing Meadows for the US Open.