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Advantages for Pittsburgh
Last year, this would have been a very, very long list. Topping it still is experience.
Kevin Kolb has a handful of starts, and there's no guarantee that he'll be the savior or the next Kurt Warner or anything of the sort. They have only one proven receiver on offense and a decent tight end who's had some injury concerns. They also have no running back. That points to the Steelers having a heavy advantage offensively.
The Steelers have a better defense and this is one of the rare teams where the Steelers can also boast of having a better secondary. Adrian Wilson is the only truly scary piece back there, so the key will simply be to stay away from him. It will be interesting to see what effect Ray Horton, their new coordinator, has on the defense's performance.
Disadvantages for Pittsburgh
If I had to pick one receiver to go to battle with, it would be Larry Fitzgerald. The guy is scary good. Now that he's got something that might be a quarterback with him, he could go back to being among the most dangerous players in the league. I'm taking any good receiver against our secondary until they prove themselves again.
The Cardinals don't really have many other advantages, but you never know when they'll show up. They came close to beating the Steelers in Super Bowl XLIII, so they've got some tricks up their sleeve.
I'm actually going to give the Steelers a heavy advantage here. They have a habit of really killing young quarterbacks, and Fitzgerald is only one man. This one devolves into a laugher as Pittsburgh wins 31-10.