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With star forward Robin Van Persie serving a suspension, tonight's contest will show how well Arsenal can cope without their influential Dutchman.
It is likely that under performing Moroccan front man Marouane Chamakh will be given another chance to recapture his form.
Chamakh looked dreadful during preseason and will need to do a lot more to convince Arsene Wenger that he still belongs in the squad.
Another option could be to deploy Gervinho through the middle. The Ivorian's excellent off the ball movement along with his strength and pace could be very effective this evening.
Arsene Wenger has even hinted that want away Danish target man Nicklas Bendtner could be given an opportunity to impress.
Given Van Persie's injury history, Arsenal must show that they can function well in his absence. If not, then Arsene Wenger will be forced into the transfer market to bolster his options at striker.
Tonight's contest is a tough fixture. The current mood of many Arsenal fans risks creating an oppressive atmosphere for a team already under intense pressure.
But this game is a perfect opportunity for Arsene Wenger and his players to show they still have the ability to compete at the highest level.
A resolute and composed performance is needed. If the Gunners can take a two-goal lead into the second leg, that will see them through.