For better or worse, Fabregas has exemplified Wenger's vision for the team throughout the last six years.
His skill and technique have been the finest examples of what Wenger has tried to achieve with this particular Arsenal squad.
The question marks concerning his abilities as a leader have represented the chief criticism levelled against Wenger's current crop of players.
But despite the lack of trophies Arsenal fans have enjoyed the privilege of watching Cesc Fabregas develop from a promising 16-year-old into the finest creative midfielder in the game.
On his Premier League debut away to Everton in August 2004, Fabregas immediately showed that he had that often indefinable something extra that meant he was destined to flourish.
By the time Arsenal had moved to the Emirates Stadium in 2006, the character of the team had shifted away from the speed based approach designed to maximise the talents of Thierry Henry.
In just two short years, the team had instead changed to a more cerebral, short passing style of play based around the play making guile of Fabregas.
Fabregas became the heartbeat of the team. Arsenal's stylish play and chances of success were entirely dependant on the performance of their Catalan skipper.
As Arsenal fans bid one of Arsene Wenger's greatest ever success stories a fond farewell, here is a look at Fabregas's five best performances.