In the middle of the 2006 season, the Twins lineup consisted of Jason Tyner batting eighth, Jason Bartlett ninth, Nick Punto first, and Luis Castillo second. These four guys were given the nickname "Piranhas" by Ozzie Gullien because of their ability to all hit like leadoff hitters, for average, and not power.
Denard Span, Alexi Casilla, Ben Revere, and Tsuyoshi Nishioka are very capable of being the new piranhas. All four of these guys hit for average and not power, and putting these guys 1,2,8,9 in the order would be great for the Twins.
With these guys hitting for average and not power, it would give the Twins a perfect balance of guys who can hit for power, and guys who can hit for average. By putting Ben Revere and Denard Span at the top of the line up, Joe Mauer and Micheal Cuddyer would have more opportunities to drive in more runs.
Revere's and Span's speed at the top of the lineup would open up a new gate for the Twins offense. They could call hit and runs, straight steals and sacrifice bunts.
Eight and nine hitters need to be scrappy, and get on any way possible. Alexi Casilla, and Tsuyoshi Nishioka are pretty scrappy hitters. They can beat out infield hits, and put the ball in play anyway they can.
Going back to this kind of offense would be the perfect balance of power and speed, something that a team needs to make a playoff run.