Peyton Manning is Peyton Manning and thus always poses the threat of throwing for 300-plus yards. Charles Woodson can keep Reggie Wayne in check, but who's going to cover Marvin Harrison and Anthony Gonzalez? Certainly not Tramon Williams.
The Colts will excel in the passing game early and often while their running game will get enough yards to keep the Packers defense honest. Even without Joseph Addai, the Colts will run around, through, and between the Packers' giddy run defense.
On offense, the Packers should find their run game for the first time this season. Ryan Grant has been a joke thus far, but his drought will end this week.
Aaron Rodgers has been held back by a "sore" shoulder the past few weeks. He should find his receivers open Sunday due to the lack of playmakers in the Colts secondary.
This one will be close throughout, but the overall talent of the Packers will prevail. Look for the Green Bay secondary to force a comeback-ending turnover.
Prediction: Packers, 31-24.