Jones was drafted in the 20th round of the 1963 draft by the New York Giants. The 378th player chosen, he was the third from last pick in the entire draft.
He was also a fifth round draft choice of the Houston Oilers of the American Football League, the 33rd player picked in the draft. Jones decided to join the Oilers, which featured Hall of Fame quarterbacks George Blanda, and head coach "Slinging" Sammy Baugh.
Also joining the Oilers in camp was undrafted rookie Willie Brown, a Hall of Fame cornerback.
Jones hurt his knee in training camp then failed his physical and was cut, along with Brown. He was then intent on proving to the Oilers they had made the wrong decision.
The Giants quickly called and gave him a plane ticket to New York City. Upon his arrival, the Giants had Jones undergo surgery on his knee. He was given the jersey No. 45, which was previously worn by Hall of Fame safety Emlen Tunnell, upon Tunnell's request.
He nicknamed Homer "Seabiscuit", after the famous racehorse, because Jones was so fast. Tunnell, now a defensive backs coach for the Giants, took the young receiver under his wing to teach him the tricks of the trade.
He spent most of his rookie year recuperating while learning the game, but did get on the field for three games that year. It was also the last year that Hall of Fame Giants like Y.A. Tittle, Andy Robustelli, and Frank Gifford would play in the NFL.
He also spent time watching players like Gifford throwing the ball up into the stands to fans after scoring a touchdown, and wanted to do the same thing when he reached the end zone.
After the season, NFL commissioner Pete Rozelle put in a rule that players would be fined $500 for doing so. Jones was making $10,000 a year then, so he knew that throwing the ball into the crowd was no longer an option.
He then thought of an alternative that would change the course of football history.
During the 1965 season, Jones was told ten minutes before a game that he would be starting. He responded by setting a Giants record, when he took a pass 89-yards for a touchdown on the first play of the game. It was the longest scoring play in the NFL that year.
Upon arriving in the end zone, he spiked the ball into the ground. It was the first time in NFL history this would happen, and there has been thousands of players to pull off the same feat since.
Though he feels celebrations have been taken way too far these days, Jones pioneered a part of the game many enjoy today.
Homer became a bigger part of the offense in his second year, catching 26 passes for 709 yards and 6 scores. He averaged a whopping 27.3 yards per catch, his career best.
In the 1966 season opener against the Pittsburgh Steelers. Jones had already scored on a 75 yard touchdown pass when he came up against Brady Keys of the Steelers.
The Giants had the ball on their own two-yard line, and Keys told Jones "What am I doing here covering you? I could be home eating chicken for dinner with my family."
Giants quarterback Earl Morrall what Homer thought. Jones said, "He's talking, so he's ready."
Morrall took the snap, reared back, and heaved the ball about 60 yards in the air. Jones snagged it and took it in for a 98-yard score. It is the longest play in the history in the franchise history of the Giants.
Homer then turned and told Keys, who was about fifteen yards behind him, "If you keep playing like that, you'll soon be eating chicken with your family every Sunday."
Jones finished the season with 48 receptions for 1,044 yards and eight touchdowns. He was a bona-fide star in New York, and was often swarmed by fans when out and about in public.
It was hard for Homer and his wife to eat dinner or watch a movie without him being bombarded with autograph requests.
The 1967 season saw him make his first Pro Bowl. He grabbed a career best 49 balls for 1,209 yards, an incredible average of 24.7 yards per catch. Jones also ran a ball 46 yards for a score. He led the NFL with 13 pass receiving touchdowns and 14 total touchdowns.
A local radio station polled fans on who the Giants MVP was, and Jones won. The station gave him a brand new convertible Cadillac for his achievement.
The Giants traded him to the Cleveland Browns for two players in 1970, including future Pro Bowl running back Ron Johnson. He had no intention of playing ever again, but was coaxed into joining the Browns by his father.
Homer had an aunt who lived in Cleveland and his father wanted him to take care of her, along with his cousin Joe "Turkey" Jones.
Upon joining the Browns, he was told that he would be the teams third receiver and return kickoffs. In the season opener, Cleveland played in the first Monday Night Football telecast on ABC. Jones led the Browns to a win by returning a kickoff 94 yards for a score, the first of its kind on MNF.
He spent the rest of the year returning 29 kicks for 739 yards, a 25.5 yards per return average. He didn't get much time on the field, but he did take one of his ten receptions 43 yards for the last touchdown of his career. He then retired after that year.
He holds the NFL record of averaging 22.3 yards per reception throughout his career. This is based on having a minimum of 200 receptions. Jones also holds the Giants franchise record for having 66.4 receiving yards per game over a career.
His 4,845 receiving yards are the fifth most, and his 35 receiving touchdowns is still tied for the fifth most in Giants history. The 218 receptions he had still ranks 18th best in team history as well.