'Toronto' Bills (Sorry everyone, had to take a stab!)
2010 Record: 4-12 (.250)
Team Needs: QB, DL, OL, LB
Buffalo enters the 2011 season with Ryan Fitzpatrick at the helm, but he shouldn't remain there long. Either Cam Newton or Blaine Gabbert is looming, just waiting to play some ball; There's no reason to believe the Bills go anywhere with the number three pick other than QB.
Buffalo has nine picks, four of which are in the top-100 of the draft, so their needs should be filled to some capacity. Assuming they choose Gabbert at three, the best available lineman should be taken at the top of the second round at number 34, preferably on the offensive side of the ball. At this point, the run on these lineman could be over, and then the Bills have to try and figure out what players are left that could benefit their team the most.
Alternatively, the Bills have a very good chance to take a primetime defensive player at three, including Marcell Darius or Von Miller, whom the Bills coached at the Senior Bowl this past season.
Now, assuming the Bills go defense with the three pick, they have a bit more room in the second round. Christian Ponder, Collin Kaepernick, Andy Dalton, Ricky Stanzi; all of these guys should be available at the start of the second round, assuming Locker goes in the mid-to-late first round.
Any of those QBs listed have enough good upside to facilitate waiting until the second round to pick up while still shoring up some defensive help. In round three and four, the Bills should focus on another lineman, or linebacker that can help the team, and if they find themselves in a good position to grab a youthful wide-out in the later rounds to help out their new passer, it always helps to have a tandem that can grow together. Preferably a receiver that won't blame God for dropping a touchdown.