While the Flyers should have a definite edge with their second seed, they struggled to close out the season, winning just seven of their final 20 games. The Sabres, on the other hand, went on an impressive 16-4-4 hot streak to make the playoffs.
The teams matchup reasonably well–the Flyers' forwards are deep and talented, their defensemen are big and physical and their goaltending is a question mark. The Sabres' forwards are small and fast, their defensemen are underrated and their goaltending is spectacular.
So what's going to happen?
Last season's Vezina Trophy winner and Olympic MVP Ryan Miller will shut out the powerful Philadelphia offense at least once in this series.
Miller's game hasn't been as good as it was last year, but he'll step up in the playoffs to give the Flyers everything they can handle.
Philadelphia Flyers rookie Sergei Bobrovsky will struggle at some point in the first round. He'll be pulled in favor of Brian Boucher during one of the games when Buffalo's offense is dominating.
Bobrovsky hasn't played a single minute of NHL playoff hockey and the pressure will get to him in the first round.
Austrian Thomas Vanek is the Buffalo Sabres' biggest game breaker and that isn't going to change when he leads this series in goals and points.
Vanek finished off the regular season as the first star of the week. He had 20 points in 17 games down the stretch, including six points in the final two games.
Both the Philadelphia Flyers and Buffalo Sabres are better on the road than they are at home. Philadelphia is the best road team in the Eastern Conference, and they're going to take advantage of that.
Philadelphia will win games three, four and six in Buffalo at the HSBC Arena after losing game one at home.
Ultimately, Philadelphia's depth, especially on offense, will overpower Buffalo in six games. The Flyers just have too much skill throughout the lineup for the Sabres defense to keep up with.
The Sabres do still have an outside chance if Ryan Miller can "Pull a Halak" and absolutely steal the series like Jaroslav Halak did for Montreal in the first two rounds last year.