Tennessee Titans (4-0) at Baltimore Ravens (2-1) Sunday 1 p.m. ET
The Titans are traveling to Baltimore to see if they can remain undefeated through five weeks. They'll face a Ravens team which is possibly going to be without RB Willis McGahee, and has only beaten a couple of teams from Ohio.
If you're in a Survivor League, this might be a good choice.
Kansas City Chiefs (1-3) at Carolina Panthers (3-1) Sunday 1 p.m. ET
These two teams have only played each other three times, and the Chiefs have won two of those meetings. LB Na'il Diggs is currently on the injury report with an illness, but the Panthers hope to have him back in action before Sunday.
Chicago Bears (2-2) at Detroit Lions (0-3) Sunday 1 p.m ET
This game will probably be the snoozer of the week. Chicago's defense will likely hold Detroit to almost nothing, while Matt Forte and Kevin Jones go to work on the Lions' front seven. Detroit won't be updating the win column this week.
Atlanta Falcons (2-2) at Green Bay Packers (2-2) Sunday 1 p.m. ET
Aaron Rodgers injured his shoulder in Green Bay's week four match-up with Tampa Bay. Apparently, he couldn't even sleep on Sunday night because of the pain. There are reports though, that he will start this Sunday regardless of whether he practices for the rest of the week. Don't be surprised if Rodgers comes out of the game and either Matt Flynn or Brian Brohm has to take the field.
None of this will affect the outcome of this game.
Indianapolis Colts (1-2) at Houston Texans (0-3) Sunday 1 p.m. ET
I bet Colts fans didn't look at the schedule in August and mark this one down as a big game. It is now though.
Manning is playing like it's still preseason, Sanders is out, and Addai is only averaging 3.3 yards per carry. But, on the bright side, Indy's O-line appears to be returning to health, which could improve all aspects of the Colts' offense.
Matt Schaub is coming off one of the best performances of his career, and the Texans seem to have found some offensive rhythm. This doesn't bode well for the Bob Sanders-less Colts
San Diego Chargers (2-2) at Miami Dolphins (1-2) Sunday 1 p.m. ET
Miami has defeated the Chargers in each of the last six times they've played each other. Was the Dolphins impressive week three victory over the Patriots just a divisional fluke, or have they stumbled across a very effective offensive game-plan?
The Chargers have been playing well, and they have a weapon in their corner which has killed them in the past: Chris Chambers. This will be a close one, but the outcome is inevitable.
Seattle Seahawks (1-2) at New York Giants (3-0) Sunday 1 p.m. ET
I've taken a lot of heat in my power rankings articles about where I place the Seahawks... which is near the bottom. New York will help me prove that I'm right about them. Hasselbeck is getting some of his receivers back this week, but that won't help them much.
Washington Redskins (3-1) at Philadelphia Eagles (2-2) Sunday 1 p.m. ET
It's gut-check time for the Philadelphia Eagles. They'll need to dig down and find a way to win without RB Brian Westbrook. Even if he plays, he will not be as effective as we all know he can be.
DeSean Jackson has played a surprisingly large role in the Eagles' offense over the last couple of weeks, and is making a case for Offensive Rookie of the Year honors. He'll need to pull out all the stops in this one.
Washington has played very, very well since losing in the NFL's season opener to the Giants. Jason Campbell has quieted his critics and Santana Moss looks like he's in his prime. This could be a high-scoring affair, but in the end...Philly knows they need this one.
I'll be previewing the late games as well as the Monday Night game later today, so stay tuned!