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During his time playing for Auburn, he ran for 4303 yards and averaged 6.6. yards per carry.
In 1982, Jackson's freshman year, he went over the top to beat Alabama and end a 9 game losing streak to the Tide and then made a one-handed grab off an option pitch as Auburn went on to defeat Doug Flutie and Boston College in the Tangerine Bowl, 33–26.
In 1983, as a sophomore, Jackson rushed for 1,213 yards on 158 carries, for an average of 7.7 yards carry. Against Alabama, Jackson rushed for 256 yards on 20 carries. Auburn finished the season by winning the Sugar Bowl where Jackson was named the Most Valuable Player. In 1984, Jackson's junior year (he missed most of the year due to injury but was still MVP of the Liberty Bowl.
In 1985, Jackson rushed for 1,786 yards and an average of 6.4 yards per rush. He won the Heisman Trophy award that year in a close vote over Iowa Quarterback Chuck Long.
Jackson's football number 34 was officially retired at Auburn in a halftime ceremony on October 31, 1992.
Jackson went on to star with the Oakland Raiders in the NFL and the Kansas City Royals and Chicago White Sox in Major League Baseball. He was an-all star in both leagues. His career in both sports was cut short by a hip injury. Despite the injury, Bo is considered by many as the greatest two sport athlete in the history of sports.