Kenny Dalglish takes charge of Liverpool in a European tie for the first time ever, as his side travels to Prague for the first leg of this last-32 tie.
And for his team selection, he is taking it seriously.
Club captain Steven Gerrard and centre-back Daniel Agger didn't travel to Prague, but Glen Johnson will make his first appearance in the tournament this season.
David Ngog starts up front for the first time under Dalglish, so Dirk Kuyt is likely to start in a slightly deeper role. Raul Meireles has recovered from an illness and retains his starting place.
At the back, Dalglish has once again gone with three centre backs. Jamie Carragher will captain the side, with Sotirios Kyrgiakos and Danny Wilson playing alongside him.
Joe Cole only starts on the bench, where he is joined by Conor Coady. Coady, who was handed the England under-19's captaincy last week, has impressed as a holding midfielder for the reserves this season and can also play as a centre back.
Starting Lineups in Full
Reina, Johnson, Carragher, Wilson, Kyrgiakos, Aurelio, Maxi, Lucas, Kuyt, Meireles, Ngog.
Blazek, Repka, Brabec, Abena, Pamic, Matejovsky, Kusnir, Vacek, Leonard Kweuke, Kadlec, Keric.