Favre sprained a joint near his right shoulder in last Sunday's game against the Buffalo Bills, leaving after just one pass.
Favre was listed as inactive before tonight's game against the Giants.
The injury ends a respected record that dated all the way back to 1992 when he played for the Green Bay Packers.
Earlier this season, Favre fractured his ankle, but still managed to start six more games.
He has seemed virtually unbreakable throughout his career, but it appears the time has come to call an end to Favre's historic streak.
Read on for more on the situation and the history of Favre's record.