Andre Johnson and Cortland Finnegan were ejected after punches were thrown during a brawl late in Sunday's game between the Houston Texans and the Tennessee Titans.
Johnson and Finnegan became tangled up during a running play in the fourth quarter.
Both players lost their helmets during the skirmish, and the normally mild-mannered Johnson threw Finnegan to the ground and began throwing punches.
Replays show that Johnson connected on at least two punches to Finnegan's face before referees managed to separate the two.
Both players were called for unsportsmanlike conduct and subsequently ejected.
Houston led 17-0 when the fight took place and went on to a 20-0 win over Jeff Fisher's struggling Tennessee team.
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In the wake of Sunday's events, it will be interesting to monitor how the NFL disciplines both players.
Johnson has no history of on-field incidents, while Finnegan is widely regarded as an irritant who embraces his reputation as a dirty player.
It appeared Finnegan was the primary instigator Sunday.
While Houston's playoff hopes are still alive, Tennessee is heading in the wrong direction in a hurry.
With rookie quarterback Rusty Smith making his first career start, the Titans totaled just 162 yards of total offense against the Texans.
Houston entered the game as one of the worst pass defenses in the NFL but allowed only 138 yards to Tennessee through the air.
Before being ejected, Johnson caught nine passes for 56 yards and a touchdown.