While Lions' rookie RB Jahvid Best failed to exploit a tasty matchup against the Buffalo Bills, veteran Fred Jackson was busy piling up the yardage.
QB Chad Pennington lasted just two plays before his season ended, WR Mike Thomas made an improbable grab that propelled his team to victory, and there were plenty of other surprises for owners throughout all of the action in Week 10.
Jon Kitna, Dallas
The veteran had his best game in a Dallas uniform as he set the pace from the very onset of this one. Better known for his proclivity to throw interceptions rather than touchdowns, Kitna torched the solid Giants secondary for 327 yards and three scores.
Although he did throw a pick, Tony Romo's backup will undoubtedly be one of the hottest names on the waiver wire this week.
Matt Cassel, Kansas City
This game was over early as Denver got out to a 35-0 start before the Chiefs even scored, but the second half belonged to the former New England Patriot.
Doing his best Tom Brady impression, Cassel amassed an incredible 469 yards passing and four touchdowns. While he did lose a fumble (that was returned for a TD), there's not much to complain about here and those who had the insight to start him against a porous Denver defense are smiling from ear to ear.
Fred Jackson, Buffalo
The Bills got their first win of the season largely in part to the effort from Jackson. Sunday's highest-scoring fantasy running back had his best day of the season, eclipsing the 100-yard barrier for the first this season.
The scat back also had six catches for 37 yards and another touchdown, and Detroit had no answer for him at any point. With rookie CJ Spiller sidelined indefinitely, it's Jackson's show to steal.
Felix Jones, Dallas
Perhaps the talent in Big D will become a little more fantasy relevant with a new coach at the helm, and Felix Jones' performance serves as a prime example.
Although he was only starting because Marion Barber chose not to follow the newly installed dress code, Jones certainly made the most of his opportunity, with most of his damage coming on a beautifully executed screen pass that went for a touchdown. It's clear that the Arkansas product will be more involved in the game plan moving forward.
Mike Thomas, Jacksonville
The play that everyone can't stop talking about, it was Mike Thomas who made the improbable grab that led the Jags to a thrilling victory over the Texans. In his first 100-yard game of the season, Thomas made a very lasting impression.
With teammate Mike Sims-Walker having a subpar season by most owners' standards, perhaps now Thomas will begin to see a bigger role in the offense and finally fill the hype that surrounded him as a popular draft day sleeper.
Wes Welker, New England
It's been a rather disappointing season for Welker and his owners as the veteran continues to rehab from reconstructive knee surgery, but if his performance against the Steelers is a sign of things to come, things are beginning to look up.
By far his best game of the season, the veteran looked as healthy as he has all year with eight catches for 89 yards. A vintage WW game by his standards, expect Brady to look his way more and more as we enter the stretch run.
Anthony Fasano, Miami
Although Fasano has been sort of hit or miss this season, the big tight end had a monstrous game this week against the Titans. Another player on the list with his first 100+ yard game of the season, Fasano stands to benefit from the uncertainty that clouds the QB position for the Dolphins after losing both Henne and Pennington (most likely) for the season.
Although he doesn't have a ton of upside, it seems that good things happen for the team when Fasano is involved from the get go, and with the TE position spreading itself rather thin, he's looking like a prime guy to target if you're in need of some help at the position.
Rob Gronkowski, New England
Arguably the most hated man in New England after Week 9's blowout loss to the Browns, Gronkowski really endeared himself to Pats fans this week with an absolutely extraordinary showing.
At 6'6", Gronk is a beast in the red zone as evidenced by his three touchdown performance. If the rookie can prove that he can hold onto the ball, his ceiling is limitless as there simply isn't a defender big enough to stay with him in pass coverage.