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Manny Pacquiao has not been knocked out in over eleven years. Antonio Margarito was just knocked out in 2009 against Shane Mosley and that is still fresh in his mind. Let's face it, Manny Pacquiao just doesn't get knocked out.
Time and time again Manny has adjusted to bigger men, taken them down and proven he can take the punishment.
Even if the more powerful Margarito can catch the quicker Pacquiao it will not be enough to end the fight early, which Margarito surely will be trying to do.
He doesn't want to be chasing Manny all over the ring for twelve rounds. But that's exactly what will happen which will tire the bigger Margarito giving Pacquiao the opening to end the fight.