If we were to look at these two teams man for man then I would say that Smackdown would win this match hands down. However its not that simple has I will look at the two teams individually. I'll start with Team Raw and it is a very impressive team.
In The Miz you have probably the hottest superstar after Randy Orton in the WWE. Alongside him there is two former world champions in Sheamus and CM Punk. Then you have, who many see as a world champion in waiting in John Morrison and his good friend R-Truth. These two should combine well in this match so that is to Raw's advantage. Then there's the powerful Ezekiel Jackson. Expect big things to come from him in this match, perhaps we'll see him overpower Big Show at some point. Now this is an impressive team but then there's Santino...
I expect nothing more but comedy from him and I believe Ted Dibiase Jr or one of the Nexus members would have been better suited for this match.
Now to analyse Team Smackdown starting with their captain the Big Show. The only man in wrestling history to hold the WCW, WWE, and ECW world titles.With him, Edge, Jack Swagger and Rey Mysterio, over half their team has been world champions. Then there is the impressive Alberto Del Rio, fan favourite Kofi Kingston and the new and improved Tyler Reks. Now as I said before on paper, Team Smackdown should win. But lets look at this on a deeper level.
Alberto Del Rio and Rey Mysterio do not like each other so don't expect them to get along during this match. Last Monday night on Raw, Jack Swagger put Edge in an ankle lock which almost cost Smackdown the battle royale. Tyler Reks doesn't look like he'll get along with anybody leaving Big Show, Kofi and Rey as the only members who can realistically get along with each other.
With Team Raw however, despite their bad break-up, Miz and Morrison were a fantasitc tag team and WWE cannot pass up the opportunity to see these two work in tandem again. In addition to this Morrison also gets on with R-Truth so there is unity within the team.
Nobody also seems to have a problem with anybody in Team Raw so I cannot see them disintergrating like I can imagine Team Smackdown will. Because of this, I think Team Raw will win this match and take the trophy back to the red half of the WWE this year.