This Sunday afternoon, the Jacksonville Jaguars travel to take on the Buffalo Bills at Ralph Wilson Stadium. Kickoff is at 1 P.M. EST, and the Bills are searching to earn their first victory of the season over the 2-2 Jags.
Last season when the teams met, Ryan Fitzpatrick was the starting quarterback for the Bills and had a huge day, throwing for 297 yards with a touchdown and two interceptions, although the Bills weren't able to come away with the win. They lost in the final minutes of the game, 18-15.
The Jaguars' star running back, Maurice Jones-Drew, was held to just 66 yards on 25 carries, and the Bills hope to have that success against the run after giving up over 200 yards last week on the ground to the New York Jets.
This game could go either way, and this slideshow takes a look at the eight most intriguing player matchups of the game.
Aaron Kampman returned to a familiar role as a 4-3 defensive end after spending a season in Green Bay playing outside linebacker in their 3-4 front, and has played solid for the Jaguars.
This week, he will be lined up with Bills left tackle Demetrius Bell, who is still adjusting to being a full time starter at the position. Kampman has made nine tackles with 1.5 sacks on the year, and Bell will finally have a game against a 4-3 defensive front.
Through the first four games, Bills opponent's utilized 3-4 defenses, and Bell struggled containing pass-rushing linebackers. This game will be his first man-to-man test against a player in a three-point stance.
Kyle Williams has made an outstanding transition to his new role as a nose tackle for the Bills 3-4 defensive scheme, and has made 19 tackles, two for a loss, and a sack, while facing double teams.
The Jaguars have solid guards in Justin Smiley and Vince Manuwai, but center Brad Meester isn't much of a test for Williams.
Williams has really been the only play maker on the Bills defense, and that will definitely continue on Sunday as he tries to clog gaps and put pressure on the Jaguars quarterback, David Garrard.
The Bills defense has struggled mightily against opposing tight ends this season, mainly due to the play of outside linebacker Chris Kelsay.
On the year, the Bills have allowed 17 catches for 231 yards and three touchdowns to opposing tight ends, and against the Jets, Dustin Keller had two of those scores.
Marcedes Lewis has played well this season, catching 12 passes for 138 yards, and caught three of David Garrard's six touchdown passes on the year.
Lewis isn't exactly a household name, but the Bills really need to know where he is lined up at all times, and maybe shade him with a safety to ensure that he doesn't become the fifth tight end in a row to shred the Bills defense.
Lee Evans has been extremely inconsistent this season, catching just ten passes for 94 yards on the year, and was held to one catch for just five yards last week.
Derek Cox is a second year cornerback, and is solidifying himself as a solid player in Jacksonville. Last year, Cox made 72 tackles and had four interceptions, and this year, opposing quarterbacks have shied away from targeting him.
Lee Evans really needs to break out of his slump and solidify himself as the true No.1 receiver on the Bills roster.
Bills cornerback Leodis McKelvin will make his second consecutive start of the season, thanks to a Terrence McGee injury that will keep him on the sidelines for a couple of weeks.
Mike Thomas is the Jaguars leading receiver and David Garrard's favorite downfield weapon. Thomas has caught 17 catches for 207 yards on the year.
Thomas is small in stature, at 5'8", 198 pounds, and won't be as physical of a matchup for McKelvin. If the Bills can shut him down, Garrard will have to turn to Mike Sims-Walker, who has been very inconsistent on the year.
Last year when the Bills faced the Jaguars, rookie guard Eric Wood suffered a nasty leg break that sidelined him for the rest of the season. Now, he and fellow second year guard Andy Levitre will look to create holes and contain rookie Tyson Alualu and Terrance Knighton.
Alualu has made seven tackles and has 1.5 sacks on the season, and Knighton has six tackles and two sacks. Levitre and Wood really need to hold their own in their matchups to allow Fred Jackson and C.J. Spiller prove that the Bills were right in trading their leading rusher, Marshawn Lynch.
Levitre and Wood have played exceptionally well this season and have contained Vince Wilfork, B.J. Raji, and some of the elite defensive tackles in the National Football League, and they hope to continue the stellar play of the Bills interior line.
The Bills will most likely be without veteran inside linebacker Andra Davis for the second consecutive week, leaving Akin Ayodele to line up inside along with Paul Posluszny.
Posluszny returned from an injury last week, and made 12 tackles against the New York Jets, and they really need to play well to shut down Maurice Jones-Drew, who hasn't played up to his potential and is looking for a breakout game against the worst rush defense in the National Football League.
Jones-Drew has 322 yards and has scored just one touchdown on the year, but the Bills have allowed opposing teams to gain 174 yards per game on the ground.
Bills wide receivers Steve Johnson and Roscoe Parrish have been a pleasant surprise for Bills fans this season, as Johnson now has touchdowns in two consecutive games, and has been the most targeted Bills receiver, with 22.
Johnson has 12 catches for 168 yards and Parrish has 10 catches for 159 yards and a touchdown.
They will be a real test for veteran Jaguars cornerback Reshean Mathis, who has always been a top-tier corner in the league. Ryan Fitzpatrick isn't afraid to throw the long ball, and the speed of Parrish and Johnson can create some good mismatches in the Bills favor.