Injuries have reared their ugly noses again with injuries to players like Ray Rice, Jahvid Best, Steven Jackson, and Pierre Thomas.
These were early-round picks that owners need to rely on every week, but with injury question marks, it is hard to rely on any of them.
Let's look at some of their match-ups with their injuries:
Ray Rice vs. Pittsburgh
Rice has a knee injury, and if that isn't bad enough, he goes up against the best defense in the NFL.
The Steelers haven't allowed a 100-yard rusher all season and they won't against a banged-up Rice. If you have other options, I'd suggest sitting him this week even if he plays.
Jahvid Best vs. Green Bay
Best has a turf toe injury and goes up against a top defense like the Packers. Best has missed multiple days of practice this week and is questionable to play.
The Packers have a top-notch run defense, so if you have better options, sit Best this week even if he plays.
Steven Jackson vs. Seattle
Jackson is dealing with a groin injury and will probably be a game-time decision.
Pick up Kenneth Darby just in case Jackson misses the game. If Jackson starts, then plug him in.
Pierre Thomas vs. Carolina
Thomas is dealing with a left ankle injury and will be a game-time decision. If Thomas starts, then you have to start him, but have other options just in case.
Here is a list of the best waiver-wire pickups this week: