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Why This Game is Important: After the 49ers' last-second defeat against the Saints on Monday night, the Chiefs-49ers Week 3 meeting features two teams heading in opposite directions. Kansas City has pulled out two wins to start the season, while Mike Singletary's team still has considerable healing to do after a brutal loss to the Seahawks and a gut-wrenching one to the Saints.
Keys to the Game: Alex Smith doesn't always get it done, but Frank Gore is Mr. Reliable. San Francisco's defense is good enough to stop the Chiefs' speedy running backs and frustrate Matt Cassel, who has yet to show he has what it takes to play quarterback for Charlie Weis. Kansas City just needs to make plays and find a way to pull out the win.
Prediction: San Francisco 20, Kansas City 10
Unless Cassel finally demonstrates the ability to get the ball to the receivers, Kansas City has little chance to defeat the 49ers, even at Arrowhead.