The Madden curse has certainly made its mark on the landscape of the NFL since players began gracing the cover in 1999.
With Drew Brees proudly adorned on the cover of Madden 11, it's not crazy to imagine him following in the footsteps of many of his predecessors who found their careers in peril shortly after being the poster boys for EA Sports.
Will misfortune befall Brees this season in New Orleans? Only time will tell, but if it happens, we will hardly be surprised.
Here's a look at 10 players who became victims of the Madden curse.