The Colts will kickoff their preseason against the San Francisco 49ers this Sunday and despite being the defending AFC Champions, they have some issues to tend to.
Injuries, injuries, injuries.
Anthony Gonzalez is coming off an injury, Bob Sanders as per usual is dealing with his own, and the secondary was plagued last season with a variety of bumps and bruises.Will offensive line changes result in positive or negative results? Who will back-up Peyton Manning?
All of these and more will be covered in the top five things to keep a lookout for come Sunday.