While some quarterbacks enter the season on the "hot seat," others start the season with all the confidence in the world before succumbing to the rigors of a 16-week season.
Even if these quarterbacks survive the season, the playoffs are a cruel mistress that has left more than one great regular season quarterback sitting on the sidelines with his head down.
These quarterbacks all have talent. Some of them might even have a great regular season.
However, these 10 quarterbacks are destined to let their fans down at some point this season.
Donovan McNabb has been to a Super Bowl in Philadelphia, but he's never won one.
That won't change in Washington.
McNabb is the poster child for an athlete that is great during the regular season but completely unreliable once the playoffs start. The only consistent thing about McNabb in the playoffs is his inconsistency.
He may get you to another Super Bowl, but he may choke the team out of the Wild Card round just as easily.
Redskins fans will not see their Super Bowl dreams fulfilled through McNabb.
Michael Vick's best days are behind him, and that's just the way it is.
While Vick won't be the starter going into Eagles camp, he is expected to figure greatly into the Eagles' plans on offense.
But there simply is too much drama around Vick, and the league has caught up to his style of play.
Don't expect Vick to have the kind of impact on offense many in Philadelphia are hoping for, and if Kevin Kolb goes down, Vick will not be the savior.
Matt Leinart always had the tools to be a great starting quarterback, but he never was able to put those tools to a truly effective use.
After continually losing the starting job to Kurt Warner, Leinart now is "the man" in Arizona. But, he's never really shown the kind of moxie a starting quarterback needs to have to be considered part of the elite. There's nothing to indicate anything has changed at this point.
To make news even worse for Cardinals fans, Leinart's backup now is Derek Anderson, meaning John Skelton may end up being the team's quarterback of the future.
Denver Broncos Head Coach Josh McDaniels is setting everyone up for disappointment by naming Kyle Orton the starter, but what choice did he have?
McDaniels has made it clear through every action this offseason that, no matter what he's saying in public, he has no confidence in Orton and already is preparing to move on without him.
When the coach has no confidence in the quarterback, that's a recipe for disaster. Orton's play this year most likely will reflect the complete lack of confidence the organization has in him.
Unless Orton starts winning out of spite, it's going to be a lot of long Sundays for Broncos fans.
Josh Freeman may have a great career, but 2010 will be a learning experience for him.
The Bucs still are in the early stages of a complete rebuild, and there are far too many questions at wide receiver and offensive line for any Bucs fan to be comfortable with.
Freeman still is too inexperienced to handle all the problems this team will face in 2010, but check back in 2011 for better results.
A raging debate just prior to the Eagles/Cowboys playoff game this past January wasn't centered around who would win.
Instead, it centered around which quarterback would choke first, Donovan McNabb, or Tony Romo?
Romo's calling card features a "choke" sign, and no one has let down Cowboys fans more in the last few years than Romo.
Romo has dropped out of the tabloids, skipped the U.S. Open qualifier to attend minicamp, and showed up for training camp this week five pounds under his target weight, so he's got that going for him.
But, that "choke" monkey is on his back, and until proven otherwise, Cowboys fans will continue to be let down.
While Ryan Fitzpatrick is pictured above, whoever ends up taking the snaps from center for Buffalo will end up disappointing someone somewhere.
The Bills are a mess that can't be fixed in one offseason.
After another allegation of rape, a complete behavioral evaluation, and a minimum four-week suspension, Ben Roethlisberger may not be the same guy he was last year.
While that may be good news on the legal front, if Roethlisberger loses a lot of his swagger as a result of his off-field actions, that could translate to a loss of swagger on the field when he returns.
Steeler Nation will not be happy with No. 7 this year.
Jets fans really want this year to be the year.
Sorry, not yet.
While Mark Sanchez should show improvement over last year, there's still much the young quarterback is going to have to learn before he can become one of the league's elite quarterbacks.
Jets fans have their hopes set way too high this year, therefore setting themselves up for the inevitable letdown.
Not that anyone is expecting Jake Delhomme to return to his 2003 form, but Cleveland Browns fans are so desperate for a winner, the disappointment factor will be multiplied by a factor of three.
Delhomme is playing behind a pretty solid line, so protection shouldn't be an issue this year, but the wide receivers have far too many questions at the moment.
Anything other than a 2-0 start is going to begin the drumbeat for a quarterback change.