The Chargers usually start the season slow, but will likely have built some steam by Week Five.
The Chargers have an almost nonexistent running game, but one of the best QBs and aerial attacks in the NFL.
On defense the Chargers follow a bend but don't break defensive philosophy, which has faired pretty well for them.
In order to win this game, on defense, the Raiders need to play physically, bring the pressure, and get to Phillip Rivers. Pretty much what they did for the first three quarters at last year's season opener—just this time for all four quarters.
They also need to contain Darren Sproles. If given the chance, he can take over a game.
On offense the Raiders need to play it smart and not force any passes and find success on the ground.
It would also help if Shawne Merriman, Vincent Jackson, and Marcus McNeil are all gone, or continuing their holdouts.
If the Raiders can get to Rivers early and often they will win.