It wasn't that long ago that Matt Hughes was unquestionably the best Welterweight the world had to offer. Hughes had a very impressive 36–4 record and had beaten some of the best the world had to offer including BJ Penn, Sean Sherk, Hayato Sakurai, Carlos Newton, and Frank Trigg just to name a few.
George St-Pierre on the other hand was this undefeated Canadian who was really yet to be tested, he had a 7-0 record and a victory over Karo Parisyan to his name but St-Pierre wasn't the accomplished Mixed Martial Artists that you see today.
Following contractual disputes between the UFC and then UFC Welterweight Champion BJ Penn he left the company to compete in Japan and Hawaii so the UFC vacated the UFC Welterweight Championship and put it up for grabs in the UFC 50 clash between George St-Pierre and Matt Hughes.
The young St-Pierre was controlled by a much larger, more experienced Mixed Martial Artist in Matt Hughes before Hughes submitted him with an arm bar with one second remaining on the clock of the first round.
Matt Hughes would continue his reign of terror of the UFC Welterweight Division defeating Frank Trigg, Joe Riggs, Royce Gracie and the returning BJ Penn and was seemingly unstoppable at this point in his career.
George St-Pierre went on a win-streak of his own defeating five game challengers the likes of BJ Penn, Frank Trigg and Sean Sherk to be named the number one contender for Matt Hughes' Welterweight Championship.
This time around it would be George St-Pierre who defeated Matt Hughes a little over a minute into the very first round via TKO stoppage. This was seen as a huge upset for the time due to Hughes' dominance over the Welterweight Division for years.
Hughes would bounce back from his defeat to the young Canadian with a victory over Chris Lytle, George St-Pierre would not have the same luck as he was knocked out in what many believe is the biggest upset in Mixed Martial Arts history by Matt Serra to lose his Welterweight Championship in his very first defense.
Matt Hughes and Matt Serra were coaches on Season Six of The Ultimate Fighter and were expected to fight at UFC 79 for Serra's Welterweight strap however Matt Serra sustained an injury training for the bout and was unable to defend his Championship against Hughes.
George St-Pierre would step up on three weeks notice for the rubber match to determine the Interim UFC Welterweight Champion with the winner facing Matt Serra once he recovered. St-Pierre once again bettered the NCAA Division I wrestler before submitting him with seconds remaining in the second round.