This Group A match between South Africa and Uruguay will prove to be an important one, as all teams in the group are tied with one point. Whoever wins this game will have an edge to reach the knockout stage over the higher seeded French and Mexican sides.
The host nation of the 2010 FIFA World Cup, South Africa has many things to be happy about coming into this match against Uruguay.
It avoided becoming the first host nation to lose its opener, and has a very good opportunity to advance to the round of 16 for the first time ever.
Bafana Bafana will have a tough opponent in Uruguay, who will look to advance to the knockout stages for the first time since 1990.
Uruguay had little offensive production in its first match against France, only producing three shots on goal. It will look to improve its production up top against South Africa, a game Uruguay expects to win, as opposed to playing France when they were content with a draw.
The last time these two teams met was in 2007, in Johannesburg, when they played to a scoreless draw.
All this being said, let's take a look at the top five players in the Group A match between South Africa and Uruguay.
Uruguay will play with three forwards in its formation, a sure sign that it is looking to score more goals against South Africa.
Diego Forlan is the team's most important striker. He is a goal-scoring machine for his club, Atletico Madrid, scoring 56 goals in the past two years alone.
He will look to perform the best he possibly can for his country, whether that means scoring goals or setting up his teammates.
Forlan will play an important position against South Africa, playing behind the two other forwards, Luis Suarez and Edinson Cavani.
A current member of the Dutch club team FC Ajax, Luis Suarez has also drawn interest from FC Barcelona and Manchester United.
Luis Suarez is Uruguay's lucky charm; when he is on target the team simply does not lose.
With five goals in Uruguay's 2010 FIFA World Cup qualifying matches, Suarez will try to continue his strong scoring in the match against South Africa.
Suarez is very a fast and skillful player who has a special place in his heart for accurate finishes.
Keep an eye on the Uruguay's third guy up top, Edinson Cavani.
One of the young stars in this year's tournament, Cavani has been chosen to fill the third forward vacancy, and he is no stranger to scoring goals.
He has scored 27 goals over the last two seasons with Palermo in the Italian Serie A. In 13 games with his country's team he has added two more goals.
Masilela plays for Maccabi Haifa in Israel, and he has been effective in the playing time given to him in this year's tournament.
In an expected change from South Africa coach Carlos Parreira, Tsepo Masilela will start at left back for his country.
He was substituted into the game in the second half against Mexico and performed very well.
This is an important change for South Africa, and will need to yield dividends in order for South Africa to win this match against the striker-laden Uruguayan side.
A member of the Everton Football Club in the Barclays Premier League, Steven Pienaar is looking to play well against Uruguay after being substituted out in South Africa's first match against Mexico.
Pienaar had a tough season with Everton, but he will be ready against Uruguay and will come out firing.
Pienaar's performances will be an indicator of South Africa's success from here on out in the tournament.
In a group where all the teams have one point and anyone can win it, Pienaar and South Africa will be determined to win and take a very important three points away from this game.