Some may be fan favorites, while others have had fans calling for their release for years.
These hitters have reached the end of the line with their current team, and it's time for both to move on.
They are all above 30, and some play for good teams while others play for bad. But they no longer hit the ball like they used to, and have become a weak link in the lineup.
Feel free to chime in with your own players who deserve to make this list...
For the past two years, it's been clear Big Papi's time is dwindling. A career .282 hitter with consistent power numbers, he has a team option looming over his head for the 2011 season.
While David Ortiz has shown improvement from his dismal .238 season a year ago, something is missing for this career DH. Striking out 42 times through 36 games thus far, he just can't catch up to the ball like he used to.
After hitting .143 in April, he has been able to hit .361 in May, but his strikeouts have failed to improve.
He also lacks the ability to walk like he used to, with only 14 through the first two months. That won't get the job done. Without the same power threat at the plate, he is seeing more pitches that he may be able to hit, but won't get him out of a jam if he struggles again.
Maybe it's steroids, maybe age finally catching up to the speed of the bat, but whatever it is, $12.5 million for next year is too much for the Red Sox to give him by exercising a team option.
Look for both sides to move on, and the Red Sox to seek a new fixture in the middle of the lineup, perhaps even this season.
With a final gasp early in the 2009 season, Brandon Inge played the best three months of baseball in his career. Inge earned himself a spot on the American League All-Star team and looked destined for the best year of his career.
But once that game ended, he quickly reverted back to his old self.
A .235 career hitter with a .305 career OBP, this 33-year-old ballplayer has somehow managed to remain a staple in the Detroit lineup year after year. With the constant excuse of bad knees used to explain to last year's struggles, Inge was supposed to begin this year where he left off in July 2009.
Unfortunately, that has not been the case. Through 45 games this year, Inge has hit .218 and struck out 41 times. Shielded by the worst bottom half of a lineup in baseball, which includes Gerald Laird (.158) and Adam Everett (.203), Inge has avoided much scrutiny.
The other factor keeping him alive is the myth he is a great fielder. While he has great range and makes exceptional plays, his overall prowess as a fielder has been overrated by those same great plays.
Beginning in 2005, he became the starting third baseman after slowly switching from catcher in 2004.
Inge has consistently been middle of the pack.
2005: .957 FPCT (12/19 qualified), 23 errors (17/19 qualified)
2006: .960 (11/20 qualified), 22 errors (17/20)
2007: .959 (14/22 qualified), 18 errors (16/22)
2008: Not qualified, moved back to catcher for part of year
2009: .955 (15/18 qualified), 20 errors (17/18)
Some fans love him for the loyalty of enduring a 119-loss season in 2003, and believe he was an integral part of turning around the franchise. Others look at him and dub him "crINGE."
But as a free agent in 2011, the time has come for both sides to move on.
The season may be early, but with A.J Pierzynski in the final year of his contract, the writing is on the wall. After some solid years for the White Sox with some interesting incidents sprinkled in between, the two sides no longer need each other.
Pierzynski is currently hitting .217 in 40 games played this year. And a bad average for him means he isn't reaching base in anyway. In 13 seasons, nine of which he played at least 100 games, Pierzynski has never walked more than 25 times in an entire year.
With little ability to get on base, the next place to look is power. Unfortunately, he lacks in this department as well. Never hitting more than 18 home runs (back in 2005), he lacks much to offer other than a lineup filler.
As for fielding, Pierzynski has always been a mediocre catcher. In 2009, he had a .233 caught-stealing percentage, 11th out of 14 qualified catchers in the category. This year, he finds himself No. 10 early in the season at .310.
With solid catching prospect Tyler Flowers waiting in the wings to be given a chance, A.J may find himself on an unfamiliar team in the coming months.
Aramis Ramirez and Derrick Lee have passed their peak as members of the Chicago Cubs.
Aramis Ramirez has struck out 40 times in 40 games this year and is hitting .160 early this season. Hindered by thumb problems this year, Ramirez has been an extreme disappointment. After an injury-plagued 2009, yet still productive, he was due for a solid comeback year.
Four home runs and 20 RBI won't make up for the lack of hits either.
A traditionally poor career fielder, including a .933 fielding percentage up to this point in 2010, Ramirez has nothing going for him currently.
Even if the thumb is the main cause of all his issues and he miraculously dominates the remaining three-fourths of the baseball season, he has the option of voiding his contract at the end of the year.
For the Cubs, paying Ramirez over $14 million next year would be a mistake.
He may be tempted to accept that contract with fears nobody would come close to offering him that amount.
The Cubs should unload him before it's too late.
Still holding a semi-regular spot in the Mariners lineup perhaps out of loyalty, Ken Griffey Jr. has approached and subsequently passed the end of the line.
After hitting .214 last year, Griffey should have done the admirable thing and retired graciously as a member of the Seattle Mariners. Instead, he has delayed his own Cooperstown welcoming and added to his resume to the list of players who couldn't let go at the right time.
Griffey currently lacks everything that made him great. He has zero home runs, only seven RBIs, and a .186 batting average. He also owns the DH role, unable to play in the field like he used to. If a player can't hit or field, it's time to hang them up.
While the Mariners lineup has embarrassed the rest of Major League Baseball (with the exception of Ichiro), Griffey has the opportunity to walk away with at least some dignity left.
Even if he's a clubhouse leader, let him take over a managerial or front office role to stick around the team in some capacity.
With having only signed a one-year deal, Ken Griffey Jr. shouldn't be ashamed to step away before it's up.
It may be tough for players to let go. Although Griffey has been forced into a more secondary role in recent weeks, he should give up his roster spot as well.
There has to be some player in the farm system that the Mariners could benefit from giving major league at-bats to.