Entering the ninth down by five, the Yankees scored three runs off of reliever Ryota Igarashi, two of which were inherited by closer Francisco Rodriguez. With two men on, two out and a full count, the closer was able to strike out Alex Rodriguez to end the game.
Santana out-pitched Yankees ace C.C. Sabathia, giving up one earned run in 7.2 innings. Sabathia only went five innings, giving up five earned runs.
Bay, who entered play with only one home run in 2010, had three RBIs in the Mets' 6-4 victory.
After a Met four run second inning, the Mets tagged on two more runs in the fifth on Sabathia. Santana was into his seventh inning of work before the Yankees pushed across their first run on a single by catcher Francisco Cervelli.