With Kansas and Villanova both out, all of the remaining No. One and No. Two seeds have legitimate title hopes.
I am going to give you five "underdogs" that might just have what it takes to win an NCAA title.
The Washington Huskies, a worthy candidate for this list, came up just short.
Despite two impressive wins so far, there chance of making it in the long run is slim compared to these five other teams.
That is not to say any of these five teams will win the championship.
I just believe they have a better chance overall than the Huskies.
As unlikely as it sounds, don't blow the Gaels off.
They coasted through the conference tournament and beat Gonzaga, whom they had already lost to twice this year.
They then dispatched a solid Richmond team in the 7-10 match-up and upset Big East heavyweight Villanova.
A tough match-up with Baylor awaits, but there is no reason to believe they can't continue their winning ways.
After Baylor, they would likely play Duke, who is arguably the weakest of the No. One seeds, despite Kansas' early exit.
As unlikely as it is to have St. Mary's be the first No. 10 seed to even win the tournament, it was just as unlikely a few weeks ago that they would even be in this tournament.
The Butler Bulldogs never quit, and though they haven't faced a true test yet, they will this weekend against Syracuse.
If the Bulldogs can solve the 2-3 zone of the Orange, they might just find themselves dancing in April.
Can you name the two teams that have made the Sweet 16 three straight years?
Michigan State and Xavier.
Xavier has already taken out Pittsburgh, the No. Three seed in the West, with sophomore sensation Jordan Crawford leading the way.
They have a tall task ahead of them against K-State, but Xavier is solid from top to bottom and could make a deep run.
Say what? Surely a No. 12 seed has no shot at a tourney title, right? Not so fast.
In their first two games the Big Red took down two ranked teams in Temple and Wisconsin with relative ease.
Kentucky, arguably the best team remaining in the tournament, will be a huge challenge.
However, if Cornell continues shooting lights out (60 percent on field goals in their first two games,) there is no doubt they could run the table.
It's unlikely a team can shoot that well for six games, but it's hard to argue with the results of their first two games.
It's true—Tennessee hasn't had a tough road their first two games.
However, they defeated both the No. One and No. Two ranked teams during the regular season.
Coach Bruce Pearl is one of the best college coaches in the country, and with Wayne Chism and J.P. Prince, the Volunteers just need a win against a tough Ohio State team and very likely will end up in the Final Four.
A No. Six seed making the championship isn't a stretch like perhaps a No. 10 or No. 12 seed, but nonetheless it would be an upset.
The truth is, in March Madness, anything is possible, and any team can win any game.
It should be another wild weekend.