In one of the biggest showdowns the English Premier League has to offer the footballing world, there are several players who could be key to acquiring victory for their club.
Liverpool has had the upper hand recently. The squad destroyed United in the same fixture last season, and thoroughly defeated United again at Anfield earlier this season.
But don't count United out just yet.
United's recent league form has been exemplary, aside from a loss to Everton. The champions are staying right on Chelsea's heels, thanks to the Londoners' inability to capitalize on several chances they have had to pull away from the title challengers.
The match at Old Trafford this weekend could go a long way toward the final outcome of the season for both sides, and as it is, there is more than pride on the line in this fixture.
Both sides need the points. Though a draw may be enough for Benitez, Ferguson knows that with Chelsea facing Blackburn and Portsmouth in the next few days, a slip by his charges deals his challenge a serious blow.
This list outlines five players from each team who could contribute significantly to the outcome of this match.