It's the consensus toughest region in the 2010 NCAA Tournament, featuring eight coaches that have Final Four experiences.
Not only is top-ranked Kansas at the top of the heap, they're joined by Ohio State, Georgetown, Maryland, Michigan State and Tennessee.
A bevy of bona-fide stars will lead their teams into first-round action, including the nation's top individual player, the Buckeyes' Evan Turner.
The road to the Final Four won't be easy in the Midwest. Here are some things to watch as things get underway.