Manchester United thrashed West Ham 4-0 last night at Upton Park; it was a stunning performance capped off by goals from Paul Scholes, Darren Gibson, Antonio Valencia and Wayne Rooney.
Later, United saw arch-rivals Manchester City defeat title rivals Chelsea in a result which means Chelsea's lead over the Red Devils has been cut to a mere two points.
However, United boss Sir Alex Ferguson has a major headache going into next week's Champions League clash with Wolfsburg and next Saturday's Premier League battle with Aston Villa.
The Red Devils, who were already without the likes of Rio Ferdinand (back), John O'Shea (dead leg), and Jonny Evans (knee) started the game at Upton Park with Gary Neville alongside Wes Brown at the back.
United's skipper Neville then came off injured in the first half with the versatile Micheal Carrick taking his place at the back. To add to United's defensive woes, their only fully fit central defender, Wes Brown, then also came off towards the end with a knock to his knee.
Nemanja Vidic is doubtful for Tuesday's game with a flu, but Sir Alex Ferguson will hope he can recover in time to make the trip to Germany.
Micheal Carrick and Darren Fletcher are set to deputise at centre-back and right-back once again unless Sir Alex Ferguson chooses to give a chance to the likes of Richie Da Laet, Corry Evans or Joe Dudgeon.
United have sent Craig Cathcart, Danny Simpson, and James Chester on loan.
Brazilian twins Rafael and Fabio are also on the injury list which means Patrice Evra is the lone regular defender available to United.
Well, needless to say, United needs the likes of Ferdinand, O'Shea, Evans, Brown, Vidic and Neville to recover as soon as possible to ensure they maintain pressure on league-leaders Chelsea.