Matt Wilansky of ESPN.com reported the American will play her first match since January of last year after winning the 2017 Australian Open.
Williams took time away from the game after she gave birth to daughter Alexis Olympia, but she will now attempt to reign supreme once again as she plays her first competitive tennis of the year.
The two-time Indian Wells champion featured at the recent Tie Break Tens event in New York and appeared in fine fettle as she entertained the crowd.
Per Wilansky, Williams said: "I had a great time. I feel so lucky to be out here, and I'm ready to play."
At 36, Williams is entering the twilight of her career, but the 23-time Grand Slam singles champion remains the benchmark her competitors must measure themselves by.