Associate head coach Larry Drew will replace Lue for the upcoming game.
Lue was in the arena for a pregame interview with Fox Sports Ohio but apparently didn't feel well enough to continue for a full game:
The 40-year-old is in his third year with the Cavaliers and hasn't missed a game, accumulating a 101-54 regular-season record plus an NBA title in 2016.
While Cleveland has won 18 of its last 20 games to move to 23-9 on the season, Chicago comes in with a seven-game winning streak after a 3-20 start to the year.
Although being without the head coach could be a problem for the Cavs, Drew has plenty of experience running a team. He spent three years in charge of the Atlanta Hawks plus one with the Milwaukee Bucks. He has been on the Cleveland staff for the past four years.