A win for Antonio Conte's side would move them level on points with the visitors, in what will be both teams' final fixture before the international break.
Here is how you can watch the game:
Date: Saturday, Sept. 30
Time: 5:30 p.m. BST/12:30 p.m. ET
TV Info: BT Sport 1, BT Sport 4K UHD (UK), NBC Sports (U.S.)
Chelsea go into the game with few injury problems; only Danny Drinkwater is sidelined and not expected back until October, per BBC Sport.
Manager Antonio Conte may make changes, however, with his side having been in Spain in midweek to take on Atletico Madrid in the UEFA Champions League.
Manchester City will be without defender Benjamin Mendy after the club confirmed he has ruptured his anterior cruciate ligament and is to undergo surgery.
Danilo could come in to replace Mendy, although manager Pep Guardiola could switch formation and use Leroy Sane or Raheem Sterling as a wing-back.
City are likely to be without Sergio Aguero following reports of him being involved in a car accident in Amsterdam that could rule him out for a couple of months, per ESPN:
This is a huge clash at the top of the table that pits two in-form teams against each other and will test the title credentials of both sides.
City head to west London having scored 16 goals without reply in their last three Premier League matches.
While the results have been impressive, the style of play this season is also proving too good for teams, as highlighted by Opta:
Chelsea are also on a good run, having beaten Stoke City 4-0 last time out, with Alvaro Morata again proving what a superb buy he has been with a hat-trick.
The Spain international is also forging a fine relationship with Cesar Azpilicueta, as shown by Squawka:
Conte will surely want to have the Belgian's creativity and ability to go past players against City, particularly with Morata in such red-hot form.
The two teams look well-matched ahead of the game, but Chelsea will need to find an answer to City's in-form forwards if they are to get anything out of the game.