Ian Rapoport of NFL Network reported the team would be making a change this week against the Cardinals' vaunted secondary.
The second-year player replaces Scott Tolzien, who was miserable in Week 1 against the Los Angeles Rams. He finished 9-of-18 for 128 yards and no touchdowns, also throwing two interceptions that were returned for scores in what became a 46-9 loss.
Damien Woody of ESPN summed up the effort:
Damien Woody @damienwoody
Scott Tolzien starting a game is an abomination2017-9-10 20:18:08
The 30-year-old is now 0-3-1 as a starter with two touchdowns and nine interceptions in his career.
Brissett fared much better in his brief playing time against the Rams, with his first pass going for 50 yards to Donte Moncrief. He finished 2-of-3 for 51 yards while leading the only touchdown drive of the game.
The 2016 third-round pick posted an 83.9 quarterback rating in three games with the New England Patriots as a rookie last season and provided a threat as a runner.
He was traded to the Colts just eight days before the regular season for receiver Phillip Dorsett. Although he is still likely unfamiliar with the system, Brissett is clearly Indianapolis' best option as the squad attempts to tread water until Luck returns.
With several issues all over the field, however, the upcoming game won't be an easy one regardless of who is under center.