According to Pro Football Talk, initial X-rays on Johnson's wrist were negative. Ian Rapoport of NFL Network reported Johnson suffered a sprained wrist. ESPN's Adam Schefter reported he'll have an MRI on Monday to determine the severity of the injury.
If Johnson is forced to miss time, it would be a nightmare scenario for the Cardinals. They rely upon him as a key component in their offense as both a rusher and pass-catcher.
The former third-round pick flashed his potential as a rookie in 2015, but he proved to be one of the NFL's most dynamic players in 2016 while earning a Pro Bowl spot and a first-team All-Pro nod. Johnson led the league with 2,118 yards from scrimmage and 20 total touchdowns, and he racked up 80 catches.
Johnson suffered a knee injury in the Cardinals' final regular-season game last year, but he avoided tendon damage and didn't need to undergo surgery, according to ESPN.com's Josh Weinfuss. His ability to stay on the field has helped fuel his success over the past two seasons.
"I never really got fatigued," Johnson said in the offseason, per Kyle Odegard of the team's official site. "Those tough defense games against Seattle and the Rams, those games might feel a little sore, but that's not until the adrenaline comes down. I never really feel too bad."
Johnson's injury will put far more pressure on the rest of the backfield until he returns. Andre Ellington and Kerwynn Williams will get the first chances at backfield touches if Johnson is unable to play in Week 2 against the Indianapolis Colts.