Michael BruckContributor ISeptember 24, 2009

PHILADELPHIA - SEPTEMBER 20:  Drew Brees #9 of the New Orleans Saints looks for an open man during a game against the Philadelphia Eagles at Lincoln Financial Field on September 20, 2009 in Philadelphia, Pennsylvania.  (Photo by Jeff Zelevansky/Getty Images)

Just like every week, the Saints will rely on a heavy pass offense. Pierre Thomas and Mike Bell are both questionable for the game. So, the Saints might bring in Hamilton. The Bills are home which is always an advantage, but will their defense be able to stop New Orleans? According to the stats of, Buffalo has the number 28 total defense (New Orleans is 21). New Orleans has the number one total offense and the Bills well, #14. To win this the Saints, of course, are going to rely mainly on their offense but also their defense (Darren Sharper) to force turnovers. Although not a great defense, the Saint's Darren Sharper has already 3 interceptions one back for a 97 yd TD return. As for the Bills, they need to find a way to cause as many turnovers as possible and get the ball out of New Orleans hands. Edwards can connect to T.O no doubt and Jackson is a great running back!! The Bills can score points we saw that against the Bucs, but can their defense stop New Orleans so they outscore the high powered, Brees led offense? My pick is New Orleans the stats really don't add up to favor Buffalo, but they are home and they possibly could stop the Saints