Despite not having home-field advantage in potential conference championship matchups against the top seeds, the second-seeded Arizona Cardinals (13-3) and New England Patriots (12-4) are the favorites to win Super Bowl 50 on February 7.
The Cardinals are 17-4 to win the big game at sportsbooks monitored by Odds Shark, while the defending Super Bowl champion Patriots are 9-2. And both teams are also favored to win the NFC and AFC, respectively.
Arizona will host the Green Bay Packers (11-6) for the second time in four weeks on Saturday after routing them 38-8 as six-point home favorites in the first meeting.
The Packers are coming off a 35-18 victory against the Washington Redskins as two-point road underdogs last Sunday but still have too many weaknesses to be considered serious contenders to win the Super Bowl, which is why they are currently listed at 12-1.
The Cardinals are arguably the most well-rounded team in the playoff field with the best head coach not named Bill Belichick in Bruce Arians. They are plus-170 (bet $100 to win $170) to take the NFC over the Carolina Panthers (15-1), who are the No. 1 seed and also 5-1 to win the Super Bowl.
The Panthers must get past the two-time defending NFC champion Seattle Seahawks (11-6) first on Sunday, though, which is one of the main reasons they are no longer favored to win it all.
The Seahawks edged the Minnesota Vikings 10-9 last Sunday but did not cover the spread as 4.5-point road favorites, and they lost the first meeting with Carolina 27-23 as seven-point home chalk in Week 6.
However, they have won seven of their last eight games, going 6-2 against the spread behind the strong play of quarterback Russell Wilson. Seattle is 11-2 on the Super Bowl betting lines and plus-350 to advance there for the third straight year.
The Patriots remain the class of the AFC as the plus-160 favorite, and they have only one real challenger on their road to repeat as conference champs. The Denver Broncos (12-4) are the No. 1 seed and the plus-200 second choice, sitting at 11-2 to win Super Bowl 50.
New England will take on the hottest team in the NFL to kick off the divisional round Saturday, with the Kansas City Chiefs (12-5) going for their 12th straight victory when they visit Foxborough. The Chiefs are plus-400 to win the AFC and 9-1 to win the Super Bowl.
The Broncos hope future Hall of Fame quarterback Peyton Manning will find enough magic in what could be his final year to knock off Belichick and longtime rival Tom Brady of the Patriots if the teams are to meet again for the AFC Championship Game.
Denver seems to have an easier path to get at least that far, as the team hosts the banged-up Pittsburgh Steelers (11-6) on Sunday, with their opponent plus-450 to win the AFC and 12-1 to win the Super Bowl.