We may only be heading into week three, but it's clear that these duos are going to be troubling secondaries all year long.
There are a few factors that went into this list such as production, potential, and durability. Taking all these factors into account, I then looked at the team they played for and the quarterback throwing them the ball. The weaker the quarterback, the less dangerous your duo becomes, no matter how talented you are.
This is a run first team, but with a running back like Adrian Peterson who could complain? Should the time come for a pass Brett Favre has two very talented wide outs to look for in Bernard Berrian and Percy Harvin.
The experienced veteran and the athletic rookie have complemented each other well so far and Harvin seems to have become a favorite target for Favre.
The newest addition to Seattle should help ease the pressure off Nate Burleson and Matt Hasselbeck.
In 2007, Burleson caught nine touchdowns and racked up almost 700 yards. Poised for a breakout year in 2008, Brleson tore his ACL and missed the majority of last season.
If Hasselbeck and Burleson can stay healthy, Houshmandzadeh and Burleson should be able to have break out numbers in a very mediocre division.
One of the most dynamic duos in the league came to an end this off-season with the departure of Marvin Harrison. This would have been the perfect opportunity for Anthony Gonzalez to come into his own but unfortunately an injury to his knee will keep him out until mid-October.
These two can do some serious damage with Wayne drawing double teams and Gonzalez capitalizing on single coverages.
The subtraction of Terrell Owens means the addition of receptions for everyone else on the field. Roy Williams hasn't really lived up to all the hype, but he has his shot to earn his star in Dallas.
If Williams doesn't step up and become a number one threat fast, this offense doesn't have a chance of keeping up in the NFC East.
An interesting combo has arrived in Buffalo this season, Terrell Owens and Lee Evans.
Both put up multiple 1,000 yard seasons and are poised for another if they can co-exist, but the key word is if.
The demand Terrell Owens imposes on a football field may be too great for both receivers to put up dynamite numbers this year, but the possibility is there for the two to make the pro bowl.
These guys have gotten off to a fast start in a division that prides itself on defense. Both Mario Manningham and Steve Smith rank in the top five for yards gained and are putting on quite a show in New York.
Before the start of the season many wondered who would capitalize on the voids left by Plaxico Burress and Amani Toomer. It's safe to say that question has been answered.
There's a lot of excitement in Green Bay this season and it starts with these two.
Greg Jennings and Donald Driver are two of the most talented wide outs in the league and they prove it every Sunday afternoon.
Jennings caught 80 passes and almost 1300 yards last season, and that was with him sharing the spotlight.
This season Driver is currently leading the way, but it's a long road ahead and this competition is one every fan can enjoy.
Perhaps the most intriguing tandem in the league, one receiver takes plays off, the other goes 100 mph every play, the result, one of the most lethal duos in the entire league.
In 2007 the Patriots offense was one of the most prolific in NFL history, and no receiver combo in the league had better numbers than Wes Welker and Randy Moss.
With a healthy Tom Brady and another weapon in Joey Galloway on the roster, the Patriots will be lighting up secondaries all season.
When you put the 2006 Super Bowl MVP on the field with the 2009 Super Bowl MVP at the same time, you can expect to win every game you play; welcome to Pittsburgh.
Hines Ward is as dangerous a receiver as he is a blocker, and that's saying something. His counterpart Santonio Holmes is already considered a top flight wide out and he's only entering his fourth year in the league.
Did you expect anyone else?
Considered the best receiver in the league, Larry Fitzgerald almost single hand-idly brought a championship home to Arizona last season. If Randy Moss is the freak then this guy has to be the super freak, or the Freakazoid.
In 2005 Fitzgerald and Anquan Boldin accomplished something that had been seen only twice before. The dangerous duo caught over 100 passes a piece in the same season.