Ah ha! So you've finally decided to get down to the fun part of fantasy football. This is the tough stuff. It separates the men from the boys. Anyone can pick out which quarterbacks will have a big year. Now you've got to decide which individual players will have the most success...at a quarterback's expense.
Some leagues will have you specifically draft linemen, or defensive backs. It's very important to figure out how your league will be organized, and how the points system will be handled.
The easiest way to include individual defensive players in your draft (if you're a first-timer) is to lump them all into one big category.
Players receive points for interceptions, fumble recoveries, forced fumbles, sacks, safeties, touchdowns, and even tackles. Just make sure you find out how many points a player can receive on defense.
If whole numbers are used (especially for tackles), you might consider taking one of these players even before a mediocre tight end.