Jae C. Hong/Associated Press
Ortiz should give Matthysse exactly the kind of fight the Argentine gunslinger has always excelled at—a high-action brawl. Matthysse's only three losses all came against boxers: Zab Judah, Devon Alexander and Danny Garcia.
And those two losses to Judah and Alexander were hotly contested, split decisions in which Matthysse dropped both men.
Against come-forward, pressure fighters, Matthysse has always taken as good as they can give while hammering them into submission.
So simply fighting his normal fight is a battle-tested strategy for Matthysse in this one. He should move inside, pound Ortiz in the body and then look to drill the taller man with an uppercut. Ortiz is probably going to put himself in position to get hit, so Matthysse should hit him two or three times and then move into position to hit him some more.
Ortiz has power, so Matthysse should probably show a bit more defensive caution than he showed against John Molina last April. Even if he can once more overcome taking damage, Matthysse is not getting any younger.
But in the heat of the exchanges, expect to see Matthysse fall back on what he knows best: beating the other man up.