Jose Mourinho's squad have started the season in confident fashion, sealing two comfortable wins against a pair of newly promoted sides. Installed as early title favourites, a trip to Merseyside will better examine their trophy credentials.
In contrast, Everton's first two games have been far more frustrating affairs. Two leads have been squandered in the closing stages leaving the Toffees with just two points from games with Leicester and Arsenal.
Last season's 1-0 win was the first of Roberto Martinez's tenure and injected life into his inaugural campaign. Evertonians will hope for a repeat scenario as they chase a fifth Premier League win in six home games with Chelsea.
Here's a look ahead to this game's defining matchups.