Stephen Brashear/Associated Press
Chargers defense versus the mobility of Kaepernick
San Diego's defense allowed four rushing touchdowns to quarterbacks last week, all of which looked effortless on tape.
When the Chargers defense takes the field on Sunday, they'll be facing yet another nimble quarterback in Colin Kaepernick, who some may consider an even bigger threat in the run game than Russell Wilson. The last thing San Diego wants to do is allow Kaepernick to find running lanes and suffer another lopsided defeat.
Chargers starters versus field conditions at Levi's Stadium
No preseason game is worth getting hurt in, especially if unstable turf is to blame. When the players and coaching staff get on the field for warmups, they'll need to take a long look at the repaired field and determine whether its safe to play on. If I'm Mike McCoy, I think twice about letting Corey Liuget and Dwight Freeney see action if the field isn't right.
Chargers front seven versus 49ers rushing attack
Seattle pounded away at San Diego's weak front seven with a ground game that was missing two starters on the offensive line and featured just a brief glimpse of Marshawn Lynch. A similar display could be in store for Sunday's game as Anthony Davis and Alex Boone will likely be missing from the right side of San Francisco's offensive line. Frank Gore, the team's leading back, had just two carries last week and could be limited as well.
Poor tackling and a lackluster effort up front allowed Seattle's run game to go off for 200-plus yards last Friday, and if the Chargers intend on preventing another outing like that one, the front seven will need to step it up on Sunday.
X-Factor: Philip Rivers
Rivers exited last week's game after just one series with the offense. With Sunday's game being considered by many as a dress rehearsal, I expect to see a lot more of No. 17 on the field in order to get a rhythm down with his receivers.
San Francisco isn't at full strength defensively, which should allow Rivers to finally put some points on the board this preseason.